Source: dvm360

A study by WSU’s Program for Individualized Medicine revealed that cats with the MDR1 genetic mutation face severe risks from eprinomectin, found in some parasite preventives. The mutation hampers protective mechanisms against the drug, leading to neurological toxicity, with symptoms like coordination loss, tremors, and coma. Out of 33 cats studied, 14 showed adverse effects solely due to the MDR1 mutation, with 8 having two copies of the gene.

Tragically, three cats died from toxicity. Katrina Mealey, DVM, PhD, a WSU veterinarian and pharmacologist who led the research, emphasized the importance of monitoring cats post-application due to delayed symptoms. She urges the FDA to reassess eprinomectin products and consider warning labels. Genetic testing is vital to identify at-risk cats, with Mealey pioneering both the mutation discovery and testing method, potentially preventing over 50% of incidents. This study highlights the necessity of caution and awareness regarding eprinomectin use in cats with the MDR1 mutation.

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