Why Are Cats Prone to Kidney Disease? A Study Points to Unusual Fats

A new study from the University of Nottingham suggests a biological reason why cats are especially prone to chronic kidney disease. Researchers found that, unlike dogs and most mammals, domestic cats accumulate unusual fats in their kidney cells, sometimes from a young age. These fats include rare modified triglycerides with unique chemical structures, such as ether linkages, which behave differently from typical fats.

The study showed that dogs do not exhibit this pattern, while wildcats only occasionally do, highlighting a distinct feature of domestic cat biology. Scientists believe this buildup of unusual fats may signal long-term stress in kidney cells, potentially contributing to damage over time and increasing disease risk.

This discovery points to cats’ unique metabolism as a key factor in their vulnerability to kidney disease. Researchers hope further study could lead to improved prevention strategies, including specialized diets or supplements, as well as better diagnostics and treatments to support feline kidney health.